My research interest is centred on developing a system-level understanding of complex biological systems. In particular, I am interested in investigating transcriptional and post-translational gene regulation involving high-dimensional data sets using computational and mathematical approaches. I also develop methods for analysis large-scale biological data. The specific problems I am working on include: 1. Human protein-DNA interactions 2. Human phosphorylation network 3. Sensitivity analysis and parameter estimation of biochemical kinetic models 4. Other ongoing projects Some problems I worked on in the past: 1. Modeling of the circadian clock in Drosophila 2. Stochastic modeling of a viral infection process 3. Parameter estimation of stochastic differential equations |